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GMP Standard Synthesis Hot Cell for Radiopharmaceutical Production Line with Class A B C Cleanliness and 10mmpb 20mmpb 50mmPb 100mmPb Lead Equivalent
| Luogo di origine | Cina |
|---|---|
| Marca | Jovi |
| Numero di modello | Jvvmed-HC |
| Quantità di ordine minimo | 1 set |
| Prezzo | $35000~$95623 |
| Imballaggi particolari | in custodia di legno |
| Tempi di consegna | 25 giorni lavorativi dopo aver ricevuto il pagamento |
| Termini di pagamento | T/T in anticipo |
| Capacità di alimentazione | 100SETS/YEAR |
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xDettagli
| Pulizia | Classe ABC | Piombo equivalente | 10 mmpb 20 mmpb 50 mmpb 100 mmpb |
|---|---|---|---|
| Materiale | Struttura in acciaio inossidabile, mattoni di piombo | Sistema operativo | Controllo dell'intelligenza artificiale |
| Metodo di purificazione | Filtro attivo in carbone, filtrazione HEPA, | Metodo di disinfezione | Luce ultravioletta e ozono |
| Opzioni alternative | Distributore manuale, distributore automatico | Nome prodotto | Sintesi Cellula calda per linea di produzione radiofarmaceutica standard GMP |
| Evidenziare | GMP Standard Synthesis Hot Cell,Real Time Dose Monitoring Hot Cell,HEPA Filtration Radiopharmaceutical Production Hot Cell |
||
Descrizione di prodotto
Synthesis Hot Cell For Radiopharmaceutical Production Line GMP Standard With In Real Time Dose Monitoring With Hepa Filtration Active Carbon Filter Negative Pressure
Key Characteristics of Radiopharmaceutical Synthesis Hot Cells
The synthesis hot cell (also known as a synthesis shielding box or hot cell) serves as the core equipment in radiopharmaceutical production processes. Its design ensures operator safety, environmental protection, and product integrity with these essential features:
1. Radiation Shielding
The most critical safety feature, providing effective shielding against high-energy gamma rays or neutrons emitted by radionuclides.
- Materials: High-density lead (Pb) bricks/plates as primary shielding, complemented by lead glass (viewing windows) and steel (structural support)
- Thickness: Precisely calculated based on radionuclide type (F-18, Ga-68, Lu-177) and activity levels, ranging from centimeters to tens of centimeters to maintain external radiation below 2.5 μSv/h
2. Containment, Negative Pressure & HEPA Filtration
- Containment: Hermetically sealed system prevents radioactive aerosol/volatile substance leakage
- Negative Pressure System: Maintains lower internal pressure than surrounding environment, ensuring inward airflow to contain contaminants
- HEPA Filtration: Multi-stage High-Efficiency Particulate Air filters capture radioactive particles, with activated carbon filters for volatile radionuclides (e.g., I-131)
3. Remote Manipulation & Automation
Advanced systems eliminate direct operator contact with radioactive materials:
- Manipulators: Master-slave systems or electric-powered units controlled via joysticks/touchscreens
- Full Automation: Computer-controlled synthesizers and Chemical Process Modules (CPM) execute complete synthesis processes (heating, cooling, liquid transfer, purification) with minimal human intervention
4. Product Protection & Aseptic Environment
Ensures radiopharmaceuticals meet sterile, pyrogen-free injection standards:
- Clean Environment: ISO Class 7 or 5 (Grade C/A) cleanliness standards
- Transfer Systems: Dedicated pass-through boxes with interlocking mechanisms and UV decontamination
- Surface Materials: Seamless, cleanable stainless steel resistant to frequent disinfection
5. Shielding Viewing Window
Multi-layered lead glass windows provide visibility while maintaining equivalent radiation shielding to surrounding walls.
6. Utilities Integration
Comprehensive support systems for production processes:
| Utility | Function |
|---|---|
| Electrical | Powers instruments, manipulators, lighting, and sockets |
| Pneumatic | Supplies compressed air/inert gases for valves and drying |
| Vacuum | Enables filtration and liquid transfer |
| Cooling/Ventilation | Maintains stable temperature via cold traps and circulation fans |
7. Monitoring & Safety Systems
- Radiation Monitoring: Continuous internal radiation level detection
- Pressure Monitoring: Real-time negative pressure status with alarm triggers
- Temperature/Smoke Sensors: Prevents overheating and fire incidents
- Safety Interlocks: Prevents unauthorized access to doors/pass-through boxes
Summary
Modern radiopharmaceutical synthesis hot cells represent sophisticated engineering systems integrating radiation shielding, containment, automation, and sterile control. Designed to meet strict GMP standards, they enable safe, efficient production while protecting personnel and the environment. Current development trends emphasize higher integration, automation, and modularization to reduce operational complexity and radiation exposure risks.
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